After experimenting nearly all day with TSW graphics settings, mainly due to excessive contrast in Niddertalbahn making in hard to see instruments in sunny conditions, I have found that setting monitors to Game mode was the most effective setting.

Screen

• Screen Windowed Full Screen (3840x2160)
• Graphics preset High

Advanced Settings

• Leave at defaults made by screen setting high set above
• Cap frame rate at 60 FPS
• Antialiasing TAA
• VSync on
• Screen percentage 87%

• Both screens at native settings
• HDR off

• Both screens set to defaults

LG

• Picture - Picture Reset
• Picture mode - RTS (will result in):
  • Brightness - 100
  • Contrast - 70
  • Sharpness - 90

BENQ

• Menu - System - Reset All
• Menu - Picture Advanced - Picture Mode - Game

Jetwash Enhancement Mod

• High

Foobian God Mode Mod

• Zoomier zoom enabled
• Default FOV 80 (loads in when middle mouse button pressed)

• Lossless Scaling looks a bit blurry when scaling from full HD or 2k to 4k.
• Lossless Scaling goes mental when fram rate drops very low.
• Oddly enough, HDR now does not improve graphics experience.